This paper provides a retrospective and prospective overview of TU Delft’s approach to engineering ethics education. For over twenty years, the Ethics and Philosophy of Technology Section at TU Delft has been at the forefront of engineering ethics education, offering education to a wide range of engineering and design students. The approach developed at TU Delft is deeply informed by the research of the Section, which is centered around Responsible Research and Innovation, Design for Values, and Risk Ethics. These theoretical (...) approaches are premised on the notion that technologies are inherently value-laden, and as such contain the possibility of fostering or hindering moral values. Each of these approaches encourages students to take a proactive attitude with respect to their projects and profession, thinking creatively about – and taking responsibility for – how to both prevent harm and do good via the technologies they help develop. To explain how this is put into practice, this paper sketches a brief history of ethics teaching at TU Delft, outlines current activities, and presents future plans for Bachelor and Master’s level engineering ethics education at TU Delft. (shrink)

Much else was done by Rose and Sullivan in their possibly conclusive attempt to restore sense to the rebus passage, but the reading super scorpionem locustam was Gaselee's, as Rose and Sullivan clearly acknowledge. This seems unluckily to have escaped B. Baldwin, otherwise he would have noticed that Gaselee also fancied in his correction an allusion to the poisoner Locusta. For those who may have difficulty in obtaining Gaselee's collotype reproduction, I quote the relevant part: ‘But what have lobsters to (...) do with poisoners? Is it permissible to see a more or less open reference to Locusta, the queen of all poisoners? If so, we have here another little piece of evidence which will help us to date the Satyricon.’. (shrink)

Much else was done by Rose and Sullivan in their possibly conclusive attempt to restore sense to the rebus passage, but the reading super scorpionem locustam was Gaselee's, as Rose and Sullivan clearly acknowledge. This seems unluckily to have escaped B. Baldwin, otherwise he would have noticed that Gaselee also fancied in his correction an allusion to the poisoner Locusta. For those who may have difficulty in obtaining Gaselee's collotype reproduction, I quote the relevant part: ‘But what have lobsters to (...) do with poisoners? Is it permissible to see a more or less open reference to Locusta, the queen of all poisoners? If so, we have here another little piece of evidence which will help us to date the Satyricon.’. (shrink)

In Appearance and Reality Bradley has much to say about relations. This is to be found particularly in Chapter 3 and Appendix B, but the whole of the book is on this subject in one way or another. His views aroused immediate opposition and Bertrand Russell, among others, strongly attacked the “doctrine of internal relations,” a phrase which, be it noted, does not occur in Chapter 3 at all and makes its appearance only as part of the controversy. Russell argued (...) that some relations at least are purely external, and that if one does not grant this one is left with no option but to reject pluralism, embrace monism, and regard all truths as analytic. With characteristic honesty Russell admitted that it was aversion to these consequences which stimulated his desire to rebut opinions of the kind that Bradley held. It is the thesis of this essay that while Bradley had something important to say about the “doctrine,” he made a more important point about relations and qualities which has been overlaid by the controversy about “internal relations,” and that this point is an extremely relevant one in the context of much modern philosophizing. I will therefore attempt first of all to draw out Bradley’s most important point about relations and qualities; secondly to consider what connection this has with the “internal relations” controversy; and thirdly to decide whether Russell was right in supposing what he did about pluralism, monism, and analytic truths. (shrink)

This article provides ethical guidance on using race in health research as a variable or in defining the study population. To this end, a plain, non-exhaustive checklist is provided for researchers and research ethics committees, preceded by a brief introduction on the need for justification when using race as a variable or in defining a study population, the problem of exoticism, that distinctions pertain between race, ethnicity and ancestry, the problematic naming of races, and that race does not serve well (...) as a presumed biological construct in genetic research. (shrink)

Circumstances have allowed me to inspect the Paris MSS. of Strabo and to collate them for a portion of Book IX. , in view of an edition of Strabo's Thessaly which Mr. A. J. B. Wace has in contemplation.

Circumstances have allowed me to inspect the Paris MSS. of Strabo and to collate them for a portion of Book IX., in view of an edition of Strabo's Thessaly which Mr. A. J. B. Wace has in contemplation.

The use of virtual fencing in pasture-grazed farm systems is currently close to commercial reality but there are no studies applying the principles of responsible research and innovation, such as foresighting, to this technology. This paper reports results of a study aimed at foresighting potential implications associated with virtual fencing of cattle. A Delphi method was used to survey the opinions of farming practitioners and researchers, using pasture-grazed cattle farming in New Zealand as a case study. The key benefits were (...) identified as environmental protection, improved feed allocation, access to previously unavailable grazing areas, labour savings and individual animal management. The five most important potential barriers identified were device reliability, farmer perception of a value proposition, ethical issues related to community perception of negative animal welfare, lack of feed budgeting skills of farmers, and excessive training time. We suggest that more knowledge is needed on ethical issues associated with VF, including understanding public opinions of such technology developments. We suggest that development and use of VF has been focussed primarily on technical features and user benefits and needs to include consideration of wider socio-ethical principles to ensure responsible innovation processes. The findings from this study will aid focussed research and development to incorporate ethically acceptable development alongside technical factors. (shrink)

It will be noticed that, in the stemma above, no line of descent is marked from the first generation registered therein to the following generations. The genealogy of the Emperor Nerva is customarily traced back to the consul of 36 b.c., M. Cocceius Nerva. This short note will underline the ancient testimony found amongst the Pseudacroniana tracing his descent from the latter's brother, the consummate diplomat. There are ramifications. Amongst the items of interest will be the light shone upon what (...) Dio and Eutropius understood to be Nerva's standing at the time of his accession. Before passing on to Pseudacron's datum, it might be worthwhile pausing on that point, as well as briefly contemplating the factors that actually bore upon the emperor's ancestral training. (shrink)

The picture of L. Appuleius Saturninus' last days is usually derived from the straightforward narrative account found in Appian's Civil Wars, an account which modern analysis has shown to be flawed. That narrative may be glossed as follows. At the consular elections for the year 99, Saturninus and Glaucia instigated the death of a more hopeful contender. Chaos followed. On the following day, when the People had made its intention to do away with the ‘malefactors’ absolutely plain, Saturninus, Glaucia and (...) the quaestor Saufeius seized the Capitol with followers from the country. The Senate voted for their suppression and Marius invested the hill. With hopes of a safe conduct, the beseiged surrendered and Marius detained them in the curia. Those who feared that the seditiosi might escape rough justice broke in and killed, amongst others, ‘a quaestor, a tribune and a praetor, still decorated with the insignia of office. Many others also perished in the stasis, including another tribune, thought to be the son of Gracchus and being a tribune for the first time on that very day’: ταμίαν τε κα⋯ δήμαρχον κα⋯ στρατηγόν, ἔτι περικειμ⋯νους τ⋯ σ⋯μβολα τ⋯ς ⋯ρχ⋯ς. πολὺς δ⋯ κα⋯ ἄλλος ὅμιλος ⋯ν τῇ στάσει δι⋯φθαρτο κα⋯ δήμαρχος ἕτερος, ⋯ το⋯ Γράκχου παῖς εἶναι νομιζ⋯μενος, πρώτην δημαρχ⋯ν ⋯κε⋯νην ⋯μ⋯ραν. (shrink)

The picture of L. Appuleius Saturninus' last days is usually derived from the straightforward narrative account found in Appian's Civil Wars, an account which modern analysis has shown to be flawed. That narrative may be glossed as follows. At the consular elections for the year 99, Saturninus and Glaucia instigated the death of a more hopeful contender. Chaos followed. On the following day, when the People had made its intention to do away with the ‘malefactors’ absolutely plain, Saturninus, Glaucia and (...) the quaestor Saufeius seized the Capitol with followers from the country. The Senate voted for their suppression and Marius invested the hill. With hopes of a safe conduct, the beseiged surrendered and Marius detained them in the curia. Those who feared that the seditiosi might escape rough justice broke in and killed, amongst others, ‘a quaestor, a tribune and a praetor, still decorated with the insignia of office. Many others also perished in the stasis, including another tribune, thought to be the son of Gracchus and being a tribune for the first time on that very day’: ταμίαν τε κα δήμαρχον κα στρατηγόν, τι περικειμνους τ σμβολα τς ρχς. πολς δ κα λλος μιλος ν τ στάσει διφθαρτο κα δήμαρχος τερος, το Γράκχου πας εναι νομιζμενος, πρτην δημαρχν κενην μραν. (shrink)

Variations in levels of apolipoprotein E have been tied to the risk and progression of Alzheimer's disease . Our group has previously compared and contrasted the promoters of the mouse and human ApoE gene promoter sequences and found notable similarities and significant differences that suggest the importance of the APOE promoter's role in the human disease. We examine here three specific single-nucleotide polymorphisms within the human APOE promoter region, specifically at -491 , -427 , and at -219 upstream from the (...) +1 transcription start site. The -219 and -491 polymorphic variations have significant association with instance of AD, and -491AA has significant risk even when stratified for the APOEepsilon4 allele. We also show significant effects on reporter gene expression in neuronal cell cultures, and, notably, these effects are modified by species origin of the cells. The -491 and -219 polymorphisms may have an interactive effect in addition to any independent activity. DNA-protein interactions differ between each polymorphic state. We propose SP1 and GATA as candidates for regulatory control of the -491 and -219 polymorphic sites. This work's significance lies in drawing connection among APOE promoter polymorphisms' associations with AD to functional promoter activity differences and specific changes in DNA-protein interactions in cell culture-based assays. Taken together, these results suggest that APOE expression levels are a risk factor for AD irrespective of APOEepsilon4 allele status. (shrink)